Work

Dendritic, Water‐Soluble, and Nonaggregated Axially Substituted Silicon Phthalocyanine as Potential Endometrial Anticancer Agent

Year: 2024

Type: article

Abstract: ABSTRACT In this work, dendritic, water‐soluble, and nonaggregated axially substituted silicon phthalocyanines (EA‐TD‐Si and EA‐TD‐SiQ) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of EA‐TD‐Si and EA‐TD‐SiQ were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of EA‐TD‐Si and EA‐TD‐SiQ on human endometrium adenocarcinoma (HEC‐1B) cells were investigated using an MTT assay. The results indicated that EA‐TD‐SiQ had high photodamage properties via singlet oxygen depending on the light dose, while EA‐TD‐Si did not show any DNA damage without light. In addition, EA‐TD‐SiQ had higher phototoxic effects than EA‐TD‐Si on HEC‐1B cells according to the MTT assay. These results revealed the potential of EA‐TD‐SiQ to be used as a PDT agent in endometrial cancer.

Source: Applied Organometallic Chemistry

DOI: 10.1002/aoc.7699

Authors: Turgut Keles, Gökçe Seyhan, Zekeriya Biyiklioglu, Kübra Kolci, Rengin Reis, Burak Barut

Institutions: Recep Tayyip Erdoğan University, Karadeniz Technical University, Yeditepe University, Acıbadem University

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,220