Asymmetric Transfer Hydrogenation of Ketones Improved by PNN–Manganese Complexes
Year: 2024
Type: article
Abstract: Chiral manganese(I) complexes that contain carbocyclic-fused 8-amino-5,6,7,8-tetrahydroquinolinyl groups that are appended with distinct para -R substituents have proven to be effective catalysts in the asymmetric transfer hydrogenation (ATH) of a wide range of ketones (48 examples). Notably, Mn2 proved to be the most productive catalyst, allowing an outstanding turnover number of 8300 with catalyst loadings as low as 0.01 mol %. Furthermore, this catalytic protocol shows considerable promise for applications in the synthesis of chiral drugs such as Lusutrombopag.
Source: The Journal of Organic Chemistry
Authors: Yi Su, Zhifeng Ma, Jingyao Wang, Libin Li, Xiuli Yan, Ning Ma, Qingbin Liu, Gregory A. Solan, Zheng Wang
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4401604693