Work

Tongue squamous cell carcinoma treated by 5-aminolevulinic acid administrated through Microdrop method

Year: 2024

Type: article

Abstract: BACKGROUND: Postoperative recurrence of tongue squamous cell carcinoma (TSCC) has always been a clinical problem for patients and doctors. Surgery and radiotherapy are the main treatment methods for TSCC, but reoperation often leads to functional impairment. Side effects of radiotherapy include mucosal gland damage, dry mouth, weakened or lost taste. Improved treatment is needed. OBJECTIVE: To evaluate the clinical outcome of a patient with TSCC treated with Microdrop aminolevulinic acid (ALA) photodynamic treatment (PDT) twice. METHODS: ALA was dissolved in 5 % lidocaine and the concentration of ALA was 20 % by Microdrop method. Then, the tumor tissue was expanded 1 cm outward, and the injection points were evenly distributed with an upper and lower left and right interval of 2-3 mm. The 1 ml syringe was used to perform the injection in the skin of the tumor area, and there was a small cuticle at each injection point. A pathologically confirmed patient with TSCC received twice Microdrop ALA-PDT treatments, which were evaluated at 1 month and 4 months later. RESULTS: was irradiated for 30 min. After two treatments, the lesions were not visible, and no recurrence occurred after 4 months of follow-up. The patient's tongue function was well preserved and the cosmetic effect was good. CONCLUSION: Microdrop ALA-PDT may be effective in the salvage treatment of select tongue squamous cell carcinoma.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2024.104308

Authors: Yong Zhang, Anqi Lyu, Fang Zhang, Lingdi Zhao, Baozhen Ma, Quanli Gao

Institutions: Zhengzhou University, Henan Cancer Hospital

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,450