Work

From cell intercalation to flow, the importance of T1 transitions

Year: 2024

Type: article

Abstract: T1 transitions, also called cell intercalations, are important sources of fluidization of epithelial cell monolayers. We use a multiphase field model to quantify this tissue fluidization in terms of the relative dispersion of cells and characterize the T1 flow profile. We show that the ensemble-averaged flow profile of a T1 transition has a saddle-point pattern accompanied by a localized burst in cell speed. Although the temporal evolution of the relative dispersion of cells depends on specific model details, the different dispersion curves collapse robustly onto a linear function of the number of T1 transitions, implying an important connection between T1 transitions and mixing in dense systems. Published by the American Physical Society 2024

Source: Physical Review Research

DOI: 10.1103/physrevresearch.6.033176

Authors: Harish P. Jain, Axel Voigt, Luiza Angheluta

Institutions: University of Oslo, Center for Systems Biology Dresden, Physics of Life, Technische Universität Dresden

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,625

Funders: European Commission, Deutsche Forschungsgemeinschaft