Year: 2024
Type: editorial
Abstract: Extract Airway inflammation drives both the development of bronchiectasis and results in the dominant clinical features. Many aetiologies of bronchiectasis, including previous infection, COPD, rheumatoid arthritis, allergic bronchopulmonary aspergillosis and toxic exposures, cause airway inflammation that damages the bronchial wall, which then allows chronic infection to be established. When bronchiectasis is caused by defects in airway immunity, although the disease maybe initiated by persistent bacterial bronchial infection, the inflammatory response to these bacteria then promotes worsening bronchiectasis through further damage to the bronchi. Once bronchiectasis is established, the degree of airway inflammation is closely correlated to the bacterial load in both stable disease and exacerbations [1–5].
Source: European Respiratory Journal
Author: Jeremy S. Brown
Institution: University College London
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4401617275