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Age-associated functional healing of musculoskeletal trauma through regenerative engineering and rehabilitation

Year: 2024
Type: article
Abstract: < 0.01) compared to age-matched controls. Aged mice display upregulation of circulating inflammatory cytokines and show no significant regenerative response to treatment, suggesting a diminished efficacy of regenerative rehabilitation in aged populations. These findings highlight the restorative potential of regenerative engineering and rehabilitation for the treatment of traumatic musculoskeletal injuries in young populations and the complimentary need for age-specific interventions and studies to serve broader patient demographics.
DOI: 10.1039/d4bm00616j
Authors: Krista M. Habing, Cynthia A. Alcazar, Victoria R. Duke, Yong How Tan, Nick J. Willett, Karina H. Nakayama
Language: English
Open Access status: green
Funders: National Science Foundation, U.S. Department of Veterans Affairs, Collins Medical Trust, MTF Biologics, Alliance for Regenerative Rehabilitation Research and Training, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Dental and Craniofacial Research, National Center for Advancing Translational Sciences, NHLBI Division of Intramural Research, National Science Foundation Graduate Research Fellowship Program
Awards: G1382130792, G2602803197, G2845478091, G3804864196, G384610352, G388286407, G4178083830, G6125054382, G831715383, Graduate Research Fellowship Program (GRFP), PORT (Portland Oral health Research Training), Engineering the Immune and Fibrotic Response in Volumetric Muscle Loss
OpenAlex ID: W4401618262
FWCI: 1.098
Cites: 65
Cited by: 10
Related to: 10