Work

Coadministration of PEGylated apohemoglobin and haptoglobin can limit vascular dysfunction in the microcirculation and prevent acute inflammation

Year: 2024

Type: article

Abstract: Coadministration of PEGylated human apohemoglobin (PEG-apoHb)-a hemopexin (Hpx) mimetic that can scavenge free heme-and human plasma-derived haptoglobin (Hp) that can scavenge hemoglobin (Hb), reduces microcirculatory dysfunction and cardiac and kidney inflammation in a Hb-challenge model.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00315.2024

Authors: Carlos J. Munoz, Daniela Lucas, Cynthia R. Muller, Jacinda Martinez, Quintin O’Boyle, Ivan S. Pires, Andre F. Palmer, Pedro Cabrales

Institutions: University of California San Diego, The Ohio State University

Language: English

Topic: Hemoglobin structure and function

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Health Sciences, National Heart, Lung, and Blood Institute

Awards: G6456612548, Bioengineering a Dual Function Protein Construct to Detoxify Heme and Hemoglobin, G8514149025, Bioengineering a novel therapeutic protein complex to minimize the effects of medical device induced hemolysis

OpenAlex ID: W4401618487

FWCI: 0.569

Cites: 47

Cited by: 3

Related to: 10