Figure 3 from Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
Year: 2024
Type: other
Abstract: Genomic landscape of high-grade serous ovarian tumors with co-occurring BRCA and RB1 alterations. A, Pathogenic germline and somatic alterations in HR and DNA repair genes detected by whole-genome sequencing and DNA methylation analysis of 126 primary HGSC samples (27) are shown, as well as alterations in immune genes and CCNE1. Samples are grouped by HR and RB1 status. Bars at the top indicate the number of alterations in each listed gene per patient. Patients are annotated with survival group (LTS, long-term survivor, OS > 10 years; MTS, mid-term survivor, OS 2–10 years; STS, short-term survivor, OS < 2 years), tumor CHORD (41) scores, and the proportion of structural variant (SV) type (DEL, deletion; DUP, duplication; INV, inversion; ITX, intra-chromosomal translocation). B, Kaplan–Meier estimates of progression-free survival (left) and overall survival (right) of patients according to HR status (BRCA1-type HRD; BRCA2-type HRD; or HRP tumors) and RB1 status (altered vs. wild-type).
Authors: Flurina A.M. Saner, Kazuaki Takahashi, Timothy Budden, Ahwan Pandey, Dinuka Ariyaratne, Tibor A. Zwimpfer, Nicola S. Meagher, Sian Fereday, Laura Twomey, Kathleen I. Pishas, Therese Hoang, Adelyn Bolithon, Nadia Traficante, Kathryn Alsop, Elizabeth L. Christie, Eun-Young Kang, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Jennifer Alsop, Matthias W. Beckmann, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Michael E. Carney, Penny Coulson, Madeleine Courtney-Brooks, Kara L. Cushing-Haugen, Cezary Cybulski, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Simon A. Gayther, Aleksandra Gentry-Maharaj, C. Blake Gilks, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Anna Jakubowska, Mercedes Jimenez-Linan, Michael E. Jones, Scott H. Kaufmann, Catherine J. Kennedy, Tomasz Kluz, Jennifer M. Koziak, Björg Kristjansdottir, Nhu D. Le, Marcin Lener, Jenny Lester, Jan Lubiński, Constantina Mateoiu, Sandra Orsulic, Matthias Ruebner, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Mark E. Sherman, Yurii B. Shvetsov, T. Rinda Soong, Helen Steed, Paniti Sukumvanich, Aline Talhouk, Sarah E. Taylor, Robert A. Vierkant, Chen Wang, Martin Widschwendter, Lynne R. Wilkens, Stacey J. Winham, Michael S. Anglesio, Andrew Berchuck, James D. Brenton, Ian Campbell, Linda S. Cook, Jennifer A. Doherty, Peter A. Fasching, Renée T. Fortner, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Linda E. Kelemen, Usha Menon, Francesmary Modugno, Paul D.P. Pharoah, Joellen M. Schildkraut, Karin Sundfeldt, Anthony J. Swerdlow, Ellen L. Goode, Anna DeFazio, Martin Köbel, Susan J. Ramus, David D.L. Bowtell, Dale W. Garsed
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4401619146