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Video S12 from CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer

Year: 2024

Type: other

Abstract: Mitosis in cell treated with eribulin+CENP-E inhibitor. Although the multipolar spindle is focused into a bipolar spindle early in mitosis, the cell enters anaphase with multiple polar chromosomes and both daughter cells die.

DOI: 10.1158/0008-5472.26711104.v1

Authors: John B. Tucker, Caleb L. Carlsen, Christina M. Scribano, Srishrika M. Pattaswamy, Mark E. Burkard, Beth A. Weaver

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4401619389

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