Work

Role of molecular adsorbent recirculating system in methotrexate-induced acute liver failure: a case report and literature review

Year: 2024

Type: article

Abstract: We describe the case of a 14-year-old girl with osteosarcoma who was treated with high-dose methotrexate (12 g/m 2 ). Twenty-four hours after the infusion, her plasma methotrexate concentration was elevated at 937 μmol/L (normal < 10 µmol/L). She exhibited severe signs of methotrexate toxicity, including encephalopathy, acute liver failure (ALF), and acute kidney injury. In this case report, we highlight the severe and rare adverse effects secondary to methotrexate administration and the efficacity of molecular adsorbent recirculating system and continuous venovenous hemodiafiltration to recover from multiple organ failure.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2024.1424919

Authors: T. Corbisier, André O. Von Bueren, W.B. Breunis, S. Grazioli

Institutions: University of Geneva, University Hospital of Geneva, University of Zurich, University Children's Hospital Zurich

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295