Mapping associations of polygenic scores with autistic and ADHD traits in a single city region
Year: 2024
Type: article
Abstract: BACKGROUND: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? METHODS: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. RESULTS: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. CONCLUSIONS: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.
DOI: 10.1111/jcpp.14047
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,530
Funders: Wellcome Trust, University Hospitals Bristol NHS Foundation Trust, National Institute for Health and Care Research, University of Bristol, Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Natural Environment Research Council
Awards: G1633672591, G1684393010, G1793884970, G1840950138, G1864101858, G2136589732, G2538597952, G2867186120, G2881790564, G3507283293, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi- generation, longitudinal resource focusing on life course health and well- being., G3987754321, G444630160, The Alan Turing Institute, Cohorts as Platforms for Mental Health research (CaP:MH), Centre for Longitudinal Studies Resource Centre 2022 - 2025, G5420266884, G5694248314, G5959006340, Mendelian randomization to hypothesis-free causal inference, G6868616705, G6907778346, Genetics and urban environments in the development of autistic spectrum traits, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being., G7990456425, G8201869620, G8502142660, G8597009950, G8795210754, G8863568867
OpenAlex ID: W4401624981