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Human enteroid monolayers as a potential alternative for Ussing chamber and Caco-2 monolayers to study passive permeability and drug efflux

Year: 2024
Type: article
Abstract: values were similar for talinolol and rosuvastatin in tissue and enteroids. Paracellular transport of enalaprilat was lower and transcellular transport of propranolol was higher in enteroids compared to tissue. Enteroids appeared show more region- specific gene expression compared to tissue. Fresh tissue and enteroid monolayers both show active efflux by P-gp and BCRP in jejunum and ileum. Hence, the use of enteroid monolayers represents a promising and versatile experimental platform to complement current in vitro models.
DOI: 10.1016/j.ejps.2024.106877
Authors: Eva J. Streekstra, Marit Keuper-Navis, Jeroen J.M.W. van den Heuvel, Petra van den Broek, Martijn W.J. Stommel, Sander Bervoets, Luke O'Gorman, Rick Greupink, Frans G.M. Russel, Evita van de Steeg, Saskia N. de Wildt
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,700
OpenAlex ID: W4401630062
FWCI: 1.677
Cites: 53
Cited by: 11
Related to: 10