Work

Leveraging genetic data to improve the care of patients with thoracic aortic dilation

Year: 2024

Type: article

Abstract: Potential future implementation of the AORTA Gene model to improve the treatment of individuals with thoracic aortic disease. The AORTA Gene model is derived from the integration of a polygenic score for ascending aortic diameter into the clinical AORTA Score. AORTA Gene can potentially be applied to determine patients who warrant screening for thoracic aortic dilation. In the future it is hoped that similar models will be able to be inform who may benefit from aggressive medical management or earlier elective surgical intervention based on individual-level risk. This figure was generated with Biorender.com

Source: European Heart Journal

DOI: 10.1093/eurheartj/ehae499

Authors: John DePaolo, David Y Zhang, Scott M Damrauer

Institutions: University of Pennsylvania, Philadelphia VA Medical Center

Language: English

Topic: Connective tissue disorders research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $6,239