Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice
Year: 2024
Type: article
Abstract: BACKGROUND: Diet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH. METHODS: We investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model. RESULTS: GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance. CONCLUSION: This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.
Source: Nutrition and Diabetes
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,590
Awards: Establishment of Standard Gut-Heart Axis Examination and Drug Discovery Platform in Developing Microbiome Diagnostic Tools and Clinical Therapeutics( II ), Investigations on the protective mechanism of “metabolic surgery”, “exercise”, and “nutrition” for NASH and liver fibrosis via gut-liver axis and development of novel microbial therapeutic strategies(2/4), Investigations on the Protective Mechanism of “Metabolic Surgery”, “Exercise”, and “Nutrition” for Nash and Liver Fibrosis via Gut-Liver Axis and Development of Novel Microbial Therapeutic Strategies( I ), Investigation on Nash Protective Microbiome by Confinement Rearing Humanized Gnotobiotic Mice with Fecal Microbiota from Super Donor, Investigations on the Protective Mechanism of “Metabolic Surgery”, “Exercise”, and “Nutrition” for Nash and Liver Fibrosis via Gut-Liver Axis and Development of Novel Microbial Therapeutic Strategies( III )
OpenAlex ID: W4401638522