Double-network polyphenol chitosan hydrogels with instant aldehyde-β-cyclodextrin-based structure as potential for treating bacterially infected wounds
Year: 2024
Type: article
Abstract: Treatment of multiple bacterial infected wounds by eliminating bacteria and promoting tissue regeneration remains a clinical challenge. Herein, dual-network hydrogels (CS-GA/A-β-CD) with snap-structure were designed to achieve curcumin immobilization, using gallic acid-grafted chitosan (CS-GA) and aldehyde-β-cyclodextrin (A-β-CD) crosslinked. A-β-CD were able to achieve rapid dissolution (≥222.35 mg/mL H 2 O ), and helped CS-GA/A-β-CD achieve rapid gelation (≤66.23 s). By adjusting the ratio of aldehyde groups of A-β-CD, mechanical properties and drug release can be controlled. CS-GA/A-β-CD/Cur exhibited excellent antimicrobial properties against S. aureus , E. coli , and P. aeruginosa . In vivo experiments demonstrated that CS-GA/A-β-CD/Cur achieved acute bacterial infection wound healing after 20th days, proving its great potential for wound dressing .
Authors: Chi-hao Gao, Li-xia Pan, Zhao-jun Tan, Hao-zhi Sun, Meng-xiao Sun, Jin-jun Wang, Xin Shen, Feng Su, Ri-lei Yu
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,260
Funders: Department of Science and Technology of Shandong Province, Ministry of Education of the People's Republic of China, Qingdao University of Science and Technology, Qingdao Municipal Science and Technology Bureau, Qingdao Collaborative Innovation Center of Marine Science and Technology, Weihai Science and Technology Development Program, Health Commission of Shandong Province, Shandong Education Science Plan, National College Students Innovation and Entrepreneurship Training Program
OpenAlex ID: W4401645327