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Visual and Auditory Sensory Impairments Differentially Relate with Alzheimer’s Pathology

Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective: We intended to investigate the relationships between visual sensory impairment (VSI) or auditory sensory impairment (ASI) and brain pathological changes associated with cognitive decline in older adults. Methods: C] Pittsburgh Compound B PET and MRI, as well as clinical assessments, were performed at baseline and 2-year follow-up. Results: = 0.753). Neither VSI nor ASI positivity was related to cerebrovascular injury, as measured based on the white matter hyperintensity volume. Conclusion: The findings suggest that VSI is probably related to AD-specific pathological changes, which possibly mediate the reported relationship between VSI and cognitive decline. In contrast, ASI appears not associated with AD pathologies but may contribute to cognitive decline via other mechanisms.
DOI: 10.9758/cpn.24.1169
Authors: Gihwan Byeon, Min Soo Byun, Dahyun Yi, Joon Hyung Jung, Nayeong Kong, Yoonyoung Chang, MUSUNG KEUM, Gijung Jung, Hyejin Ahn, Jun-Young Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Dong Young Lee
Institutions: Kangwon National University, Kangwon National University Hospital, Seoul National University, Seoul National University Hospital, Chungbuk National University, Chungbuk National University Hospital, SNUH SMG-SNU Boramae Medical Center
Language: English
Field: Medicine
Open Access status: diamond
Funders: Seoul National University, Ministry of Science, ICT and Future Planning, Ministry of Health and Welfare, Korea Health Industry Development Institute, National Institute on Aging, National Institute of Environmental Health Sciences
Awards: G1490616775, G2359775486, G2558706190, G2688661165, G4583332562, G7470891030, KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems Biology, G937924548
OpenAlex ID: W4401646325
FWCI: 0.268
Cites: 57
Cited by: 1
Related to: 10