Year: 2024
Type: article
Abstract: Cephalofurimazine (CFz), when paired with Antares luciferase, shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain imaging. This bioluminescence provides a less invasive method for real-time monitoring of deep brain activity, with the potential to advance targeted therapies and deepen our understanding of brain functions. Further molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.
Source: BMEMat
DOI: 10.1002/bmm2.12115
Authors: Shumao Xu, Farid Manshaii, Jun Chen
Institution: University of California, Los Angeles
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Funders: Brain and Behavior Research Foundation, American Heart Association, National Institutes of Health, University of California, Los Angeles, Office of Naval Research, National Cancer Institute, Clinical and Translational Science Institute, University of California, Los Angeles, School of Engineering and Applied Science, University of Virginia
Awards: G1472059943, A soft magnetoelastic microneedle patch for rapid skin cancer screening, G4893525019, A Smart Stent Bioelectronics for Self-Powered In-stent Re-stenosis Diagnosis, An injectable and retrievable liquid bioelectronics for cardiovascular biomonitoring, Self-Powered Magnetoelastic Sensor Array for Postoperative Myocardial Strain Mapping, G7433102004, G8876996369, G9000313041
OpenAlex ID: W4401669958