Work

Immunoaffinity-free chromatographic purification of ovarian cancer biomarker CA125 (MUC16) from blood serum enables mass spectrometry characterization

Year: 2024

Type: article

Abstract: ), suggesting that this strategy of enrichment and bottom-up proteomics can enable analysis of CA125 from the serum of individuals with early-stage ovarian cancer and those whose tumors express CA125 (MUC16) at low levels.

Source: Analytical Methods

DOI: 10.1039/d4ay01172d

Authors: Naviya Schuster-Little, Andrew D. Sokolovsky, Ashten Gentry, Anita Saraf, Mark R. Etzel, Manish S. Patankar, Rebecca J. Whelan

Institutions: University of Kansas, University of Wisconsin–Madison

Language: English

Topic: Advanced Proteomics Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Wisconsin-Madison, University of Kansas, National Institutes of Health, Department of Obstetrics and Gynecology, University of Wisconsin-Madison, NIH Office of the Director, National Cancer Institute, National Institute of General Medical Sciences

Awards: G3801195781, G4388771807, Targeted proteomics of MUC16 to enable early detection of ovarian cancer recurrence, G769817697, Leveraging Big Data to Improve Women's Health (BD-WH)

OpenAlex ID: W4401699698

FWCI: 0.624

Cites: 35

Cited by: 5

Related to: 10