Assessing sociodemographic and regional disparities in Oncotype DX Genomic Prostate Score uptake
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The Oncotype DX Genomic Prostate Score (ODX-GPS) is a gene expression assay that predicts disease aggressiveness. The objective of this study was to identify sociodemographic and regional factors associated with ODX-GPS uptake. METHODS: Data from Surveillance Epidemiology and End Results registries on men with localized prostate cancer with a Gleason score of 3 + 3 or 3 + 4, PSA ≤20 ng/mL, and stage T1c to T2c disease from 2013 through 2017 were linked with ODX-GPS data. Census-tract level neighborhood socioeconomic status (nSES) quintiles were constructed using a composite socioeconomic score. Multivariable logistic regression was used to estimate the associations of ODX-GPS uptake with age at diagnosis, race and ethnicity, nSES, geographic region, insurance type, and marital status, accounting for National Comprehensive Cancer Network risk group, year of diagnosis, and clustering by census tract. RESULTS: Among 111,434 eligible men, 5.5% had ODX-GPS test uptake. Of these, 78.3% were non-Hispanic White, 9.6% were Black, 6.7% were Hispanic, and 3.6% were Asian American. Black men had the lowest odds of ODX-GPS uptake (odds ratio, 0.70; 95% confidence interval [CI], 0.63-0.76). Those in the highest versus lowest quintile of nSES were 1.64 times more likely (95% CI, 1.38-2.94) to have ODX-GPS uptake. The odds of ODX-GPS uptake were statistically significantly higher among men residing in the Northeast, West, and Midwest compared to the South. CONCLUSIONS: Disparities in ODX-GPS uptake by race, ethnicity, nSES, and geographical region were identified. Concerted efforts should be made to ensure that this clinical test is equitably available.
Source: Cancer
DOI: 10.1002/cncr.35511
Authors: Nita H. Mukand, Ekaterina Chirikova, Daphne Lichtensztajn, Serban Negoita, Tamer Aboushwareb, John Bennett, James D. Brooks, John T. Leppert, Benjamin I. Chung, Christopher Li, Stephen M. Schwartz, Susan T. Gershman, Tabassum Insaf, Bozena M. Morawski, Antionette Stroup, Xiao‐Cheng Wu, Jennifer A. Doherty, Valentina I. Petkov, Joao Paulo Zambon, Scarlett Lin Gomez, Iona Cheng
Institutions: University of California, San Francisco, National Cancer Institute, Pacific Edge Limited (New Zealand), Stanford Medicine, University of Washington, Fred Hutch Cancer Center, Massachusetts Department of Public Health, New York State Department of Health, University at Albany, State University of New York, Rutgers, The State University of New Jersey, Rutgers Cancer Institute, Louisiana State University Health Sciences Center New Orleans, University of Utah, Huntsman Cancer Institute, UCSF Helen Diller Family Comprehensive Cancer Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: University of Southern California, Cancer Registry of Greater California, National Institutes of Health, Centers for Disease Control and Prevention, University of California, San Francisco, National Institute on Aging, National Cancer Institute, National Center for Chronic Disease Prevention and Health Promotion, National Institute on Minority Health and Health Disparities
Awards: G1352184354, G1666956106, G2337224928, G26190906, G3467199957, G3669704242, G3935256369, G3987779641, G4180557805, G4854421162, G4878091559, G504639888, G5601524489, G5778816553, G611671633, G671936517, G6904952899, G6951404960, G7290139498, G7409959533, G8083727551, G8380263711, G8509442309, G8675407700, G9000038338, G946791773
OpenAlex ID: W4401700161