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Recombinant human interleukin-2 corrects NK cell phenotype and functional activity in patients with post-COVID syndrome

Year: 2024
Type: article
Abstract: Post-COVID syndrome develops in 10–20% of people who have recovered from COVID-19 and it is characterized by impaired function of the nervous, cardiovascular, and immune systems. Previously, it was found that patients who recovered from infection with the SARS-CoV-2 virus had a decrease in the number and functional activity of NK cells. The aim of the study was to assess the effectiveness of recombinant human interleukin-2 administered to correct NK cell phenotype and functional activity in patients with post-COVID syndrome. Patients were examined after 3 months for acute COVID-19 of varying severity. The phenotype of the peripheral blood NK cells was studied by flow cytometry. It was found that disturbances in the cell subset composition in patients with post-COVID syndrome were characterized by low levels of mature (p=0.001) and cytotoxic NK cells (p=0.013), with increased release of immature NK cells (p=0.023). Functional deficiency of NK cells in post-COVID syndrome was characterized by lowered cytotoxic activity due to the decreased count of CD57+ (p=0.001) and CD8+ (p 0.001) NK cells. In the treatment of patients with post-COVID syndrome with recombinant human interleukin-2, peripheral blood NK cell count and functional potential were restored. In general, the effectiveness of using recombinant human interleukin in treatment of post-COVID syndrome has been proven in patients with low levels of NK cells. This article is a translation of the article by Savchenko AA, Kudryavtsev IV, Isakov DV, Sadowski IS, Belenyuk VD, Borisov AG. Recombinant Human Interleukin-2 Corrects NK Cell Phenotype and Functional Activity in Patients with Post-COVID Syndrome. Pharmaceuticals. 2023;16(4):537. DOI: 10.3390/ph16040537 Published with the permission of the copyright holder.
DOI: 10.17816/ci635092
Authors: Andrei A. Savchenko, Igor V. Kudryavtsev, Dmitry V. Isakov, Ivan S. Sadowski, Vasily D. Beleyuk, Alexandr G. Borisov
Institutions: Krasnoyarsk Scientific Center, Research Institute of Medical Problems of the North, Siberian Branch of the Russian Academy of Sciences, Far Eastern Federal University, Institute of Experimental Medicine, First Pavlov State Medical University of St. Petersburg
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4401705190
FWCI:
Cites: 59
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Related to: 10