Design, Synthesis, and Biological Evaluation of Quinoline (Quinolinone) Derivatives as NADPH Oxidase ( NOX ) Inhibitors
Year: 2024
Type: article
Abstract: ABSTRACT NADPH oxidases (NOXs) are the sole enzyme in the human body that can directly produce reactive oxygen species. Recent studies have shown that NOXs is a very promising target for the treatment of diabetic nephropathy (DN). Here, a series of quinoline(quinolinone) derivatives have been designed based on pharmacophore strategy, synthesized and evaluated. Among them, 19d exhibits potent antiproliferative and NOXs inhibitory activities, and is worthy for further investigation.
Source: Chemical Biology & Drug Design
DOI: 10.1111/cbdd.14610
Authors: Lei Zhang, Xinliang Yang, Rui Yi, Siming Wu, Qianbin Li, Gaoyun Hu, Zhuo Chen
Institutions: Central South University, Hunan University of Medicine
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G5183022067, G7292396602, G7882182022
OpenAlex ID: W4401715316