Work

Risk of Periodontitis in Adolescents With Attention Deficit Hyperactivity Disorder: A Cohort Study of 81,055 Participants

Year: 2024

Type: article

Study design: Observational Study

Abstract: Objectives: Previous studies have demonstrated poor oral hygiene in children with attention deficit hyperactivity disorder (ADHD). However, the association between ADHD and periodontitis is still unclear. Methods: In all, 16,211 adolescents with ADHD and 162,110 age- and sex-matched controls participated in the study between 2001 and 2011. To identify the occurrence of periodontitis, the participants were followed up till the end of 2011. Confounding factors, including smoking, diabetes, and depressive disorder, were assessed and adjusted in the Cox regression models. Results: Adolescents with ADHD ( HR: 2.29) were more likely to develop periodontitis later in life than controls. We additionally observed the beneficial effect of atomoxetine ( HR: 0.42) on the periodontitis risk among adolescents with ADHD. However, this finding should be interpreted cautiously given the small sample ( n = 290) of children taking atomoxetine in the present study. Conclusions: ADHD is an independent risk factor for subsequent periodontitis development. Oral health should be closely monitored in adolescents with ADHD. Future investigation of the shared pathomechanisms between periodontitis and ADHD is warranted.

Source: Journal of Attention Disorders

DOI: 10.1177/10870547241273093

Authors: Ju-Wei Hsu, Li-Chi Chen, Kai-Lin Huang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Wen-Liang Lo, Mu-Hong Chen

Institutions: National Yang Ming Chiao Tung University, Taipei Veterans General Hospital, Cheng Hsin General Hospital

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Academia Sinica, Ministry of Science and Technology, Taiwan, University System of Taiwan, National Taiwan University, Yen Tjing Ling Medical Foundation, Tri-Service General Hospital, Taipei Veterans General Hospital, Kaohsiung Veterans General Hospital

Awards: G1259558558, G2191060952, G2205640134, G2521928599, G2530793813, G265016787, G2889430041, G3108854269, Low-Dose Ketamine Infusion among Adolescents with Treatment-Resistant Depression: a Randomized, Double-Blind Placebo-Control Study, G3758813513, G4213487846, G4427410683, G449856906, G4567487053, G4942875564, G5012695417, Modulation of the Antidepressant and Antisuicidal Efficacy of Low-Dose Ketamine Infusion via the Mtorc1 Modulator, Rapamycin: a Double-Blind, Randomized, Placebo Controlled Trial Combined with the Neuropsychological and Functional Connectivity Mri Study., Anti-Inflammation Treatment of Mood Disorders and Deep Learning Prediction Model, Emotional Dysregulation as a Transdiagnostic Clinical Domain between Adolescent Adhd and Major Affective Disorders: a Prospective Neuroimaging and Neuropsychological Study, Low-Dose Ketamine Infusion among Adolescents with Treatment-Resistant Depression: a Randomized, Double-Blind Placebo-Control Study., G8821328323

OpenAlex ID: W4401715788

FWCI:

Cites: 25

Cited by:

Related to: 10