Work

Association Between SARS-CoV-2 Infection During Pregnancy and Gestational Diabetes: A Claims-based Cohort Study

Year: 2024

Type: article

Abstract: INTRODUCTION: Coronavirus disease 2019 (COVID-19) may be associated with gestational diabetes mellitus (GDM); however, evidence is limited by sample sizes and lack of control groups. METHODS: To assess the GDM risk after COVID-19 in pregnancy, we constructed a retrospective cohort of pregnancies ending March 2020-October 2022 using medical claims. People with COVID-19 diagnosis claims from conception to 21 gestational weeks (n = 57 675) were matched 1:2 to those without COVID-19 during pregnancy (n = 115 350) by age range, pregnancy start month, and encounter year-month. GDM (claim ≥23 gestational weeks) relative risk and risk difference overall, by race and ethnicity, and variant period were estimated using log-binomial models. RESULTS: GDM risk was higher among those with COVID-19 during pregnancy compared to those without (adjusted risk ratio [aRR] = 1.12; 95% confidence interval [CI], 1.08-1.15). GDM risk was significantly associated with COVID-19 in non-Hispanic White (aRR = 1.08; 95% CI, 1.04-1.14), non-Hispanic Black (aRR = 1.15; 95% CI, 1.07-1.24), and Hispanic (aRR = 1.17; 95% CI, 1.10-1.24) groups. GDM risk was significantly higher during pre-Delta (aRR = 1.17; 95% CI, 1.11-1.24) compared to Omicron (aRR = 1.07; 95% CI, 1.02-1.13) periods, but neither differed from the Delta period (aRR = 1.10; 95% CI, 1.04-1.17). The adjusted risk difference was 0%-2% for all models. CONCLUSIONS: COVID-19 during pregnancy was modestly associated with GDM in claims-based data, especially during earlier SARS-CoV-2 variant periods. Because these associations are based on COVID-19 in claims data, studies employing systematic testing are warranted.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciae416

Authors: Oscar Rincón-Guevara, Bailey Wallace, Lyudmyla Kompaniyets, Catherine E Barrett, Lara Bull-Otterson

Institutions: Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, National Center for Chronic Disease Prevention and Health Promotion, National Center for Emerging and Zoonotic Infectious Diseases

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,001