Work

Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO3/PhSeSePh System under Acidic Conditions

Year: 2024

Type: article

Abstract: This manuscript reports a novel method for the direct iodination of the C‐4 pyrazole ring generated in situ by the reaction of 1,1,3,3‐tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO3) is used as the iodinating agent and (PhSe)2 is used as catalysts under acidic conditions. This protocol provides a convenient method for the efficient synthesis of 4‐iodo‐1‐aryl‐1H‐pyrazoles, valuable intermediates for several different coupling reactions.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202400749

Authors: Thiago J. Peglow, João Pedro S. S. C. Thomaz, Patrick C. Nobre, Cecilia Scimmi, Claudio Santi, Vanessa Nascimento

Institutions: Universidade Federal Fluminense, University of Perugia

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Instituto Nacional de Ciência e Tecnologia de Catálise em Sistemas Moleculares e Nanoestruturados