An emerging epidemic of allergic contact dermatitis due to phytonadione epoxide (oxidised vitamin K1)
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Reports of allergic contact dermatitis (ACD) to phytonadione epoxide (PE) in cosmetics suggest that PE is as powerful a sensitiser as its parent compound phytonadione. OBJECTIVE: To evaluate a case series of ACD to PE in Spain. METHODS: We reviewed the records of 20 patients with ACD to cosmetics containing PE diagnosed across Spain between January 2019 and June 2023. RESULTS: All 20 patients developed patch test (PT) or repeated open application test (ROAT) reactions to cosmetics containing PE. All involved women with eyelid eczema. PT or ROAT with PE preparations were positive in 17/20 (85%). PE at 1%, 5%, 10% and 20% in pet. was patch-tested in 8/17, 14/17, 11/17 and 8/17 patients; being positive in 6/8 (75%), 13/14 (92.85%), 11/11 (100%) and 8/8 (100%), respectively. CONCLUSION: Regulators should, not only ban the specific dangerous cosmetic ingredients, but also consider to ban or keep under close surveillance those closely related products or derivatives that might potentially cause similar harmful effects. PTs with PE are suggested to be performed at a 5% concentration in pet. Higher concentrations (10% pet.) should be tested whenever PTs with 5% pet. PE are negative.
Source: Contact Dermatitis
DOI: 10.1111/cod.14675
Authors: María E. Gatica‐Ortega, María A. Pastor‐Nieto, Ana María Giménez‐Arnau, Pedro Mercader‐García, Esther Serra‐Baldrich, Violeta Zaragoza‐Ninet, Tatiana Sanz‐Sánchez, Araceli Sánchez‐Gilo, David Pesqué, Fátima Tous‐Romero, Francisco Javier Ortiz‐de‐Frutos, Eduardo de la Rosa‐Fernández, Sara Dorta‐Alom, Marta Elosua‐González, Ricardo González‐Pérez, José Manuel Carrascosa‐Carrillo, Mónica Munera‐Campos, Juan Francisco Silvestre‐Salvador, Javier Miquel‐Miquel, Antonio de Mateo Minguez, Leopoldo Borrego
Institutions: Complejo Hospitalario Universitario de Toledo, Hospital Universitario de Toledo, University of Castilla-La Mancha, Universidad de Alcalá, Hospital Universitario de Guadalajara, Hospital Universitario Fundación Jiménez Díaz, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, Hospital del Mar Research Institute, Hospital General Universitario Morales Meseguer, Hospital de Sant Pau, Hospital General Universitario De Valencia, Hospital Universitario Infanta Sofía, Hospital Universitario Rey Juan Carlos, Hospital Universitario 12 De Octubre, Hospital Universitario Nuestra Señora de Candelaria, Hospital Universitario Puerta de Hierro Majadahonda, Hospital Universitario Araba, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Hospital General Universitario de Alicante Doctor Balmis, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital Arnau de Vilanova, Universidad de Las Palmas de Gran Canaria, Hospital Universitario Insular de Gran Canaria
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4401728813