Work

Agonist Discovery for Membrane Proteins on Live Cells by Using DNA-encoded Libraries

Year: 2024

Type: article

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.4c08624

Authors: Yiran Huang, Rui Hou, Fong Sang Lam, Yunxuan Jia, Yu Zhou, Xun He, Gang Li, Feng Xiong, Yan Cao, Dongyao Wang, Xiaoyu Li

Institutions: State Key Laboratory of Synthetic Chemistry, University of Hong Kong, Innovation and Technology Commission, Shenzhen Bay Laboratory, Second Military Medical University

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Research Grants Council, University Grants Committee, Science and Technology Commission of Shanghai Municipality, Innovation and Technology Commission, Shenzhen Bay Laboratory, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G2567706635, Identification of extracellular ligands of integrins on cancer cells using DNA-programmed photo-affinity labelling, Selection of DNA-encoded chemical library against protein targets with distal ligand-binding sites for multivalent ligand discovery, G4124643817, G4539660537, Target-guided selection of DNA-encoded chemical libraries for macrocycle ligand discovery, G520648074, Ligand discovery for membrane proteins on the surface of live cells using DNA-encoded libraries, G6535558259, G7066605917, G7512716987, Selection of DNA-encoded Libraries (DELs) for the Development of PROteolysis TArgeting Chimeras (PROTACs) and the Exploration of E3 Ligase Space, G8325032120, G942926612

OpenAlex ID: W4401733847

FWCI: 3.003

Cites: 77

Cited by: 26

Related to: 10