Alterations in aperiodic and periodic EEG activity in young children with Down syndrome
Year: 2024
Type: article
Study design: Observational Study
Abstract: Down syndrome (DS) is the most common cause of intellectual disability, yet little is known about the neurobiological pathways leading to cognitive impairments. Electroencephalographic (EEG) measures are commonly used to study neurodevelopmental disorders, but few studies have focused on young children with DS. Here we assess resting state EEG data collected from toddlers/preschoolers with DS (n = 29, age 13-48 months old) and compare their aperiodic and periodic EEG features with both age-matched (n = 29) and developmental-matched (n = 58) comparison groups. DS participants exhibited significantly reduced aperiodic slope, increased periodic theta power, and decreased alpha peak amplitude. A majority of DS participants displayed a prominent peak in the theta range, whereas a theta peak was not present in age-matched participants. Overall, similar findings were also observed when comparing DS and developmental-matched groups, suggesting that EEG differences are not explained by delayed cognitive ability.
Source: Neurobiology of Disease
Institutions: Boston Children's Hospital, Harvard University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,430
Awards: G1065523186, G1649372110, Neural Markers of Language Development in Fragile X Syndrome and Autism Spectrum Disorder, G8809709093, G9000055236, G9000076522, G9000143013, Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center, Translational Post-doctoral Training in Neurodevelopment
OpenAlex ID: W4401745176