Work

A core proteome profile unites mouse models and patients in Alzheimer disease

Year: 2024

Type: article

Abstract: Levites et al. demonstrate that mouse models of Alzheimer disease (AD), exhibiting amyloid-beta (Αβ) plaque formation, share Αβ responsome proteins with humans. Their work underscores the value of these models in studying Αβ aggregation, cellular vulnerability, and early-stage AD pathology. Levites et al. demonstrate that mouse models of Alzheimer disease (AD), exhibiting amyloid-beta (Αβ) plaque formation, share Αβ responsome proteins with humans. Their work underscores the value of these models in studying Αβ aggregation, cellular vulnerability, and early-stage AD pathology.

Source: Cell Reports Medicine

DOI: 10.1016/j.xcrm.2024.101683

Authors: Grigoria Tsaka, Frederic Rousseau, Joost Schymkowitz

Institutions: VIB-KU Leuven Center for Brain & Disease Research, KU Leuven

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,460