Baseline Viral Load and On-Treatment Hepatocellular Carcinoma Risk in Chronic Hepatitis B: A Multinational Cohort Study
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) risk persists in patients with chronic hepatitis B (CHB) despite antiviral therapy. The relationship between pre-treatment baseline hepatitis B virus (HBV) viral load and HCC risk during antiviral treatment remains uncertain. METHODS: IU/mL) who initiated entecavir or tenofovir treatment. The primary outcome was on-treatment HCC incidence, stratified by baseline HBV viral load as a categorical variable. RESULTS: IU/mL, who exhibited the lowest HCC risk. CONCLUSION: Baseline viral load showed a significant, non-linear, parabolic association with HCC risk during antiviral treatment in noncirrhotic patients with CHB. Early initiation of antiviral treatment based on HBV viral load may help prevent irreversible HCC risk accumulation in patients with CHB.
Authors: Won-Mook Choi, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, W. Ray Kim, Leland J. Yee, Craig Brooks-Rooney, Tristan Curteis, Laura J. Clark, Zarena Jafry, Chien-Hung Chen, Chi-Yi Chen, Yi-Hsiang Huang, Young-Joo Jin, Dae Won Jun, Jin-Wook Kim, Neung Hwa Park, Cheng-Yuan Peng, Hyun Phil Shin, Jung Woo Shin, Yao-Hsu Yang, Young-Suk Lim
Institutions: Asan Medical Center, University of Ulsan, Chinese University of Hong Kong, Stanford Medicine, Stanford University, Gilead Sciences (United States), Costello Medical Consulting (United Kingdom), Chang Gung University, Kaohsiung Chang Gung Memorial Hospital, Chia-Yi Christian Hospital, National Yang Ming Chiao Tung University, Taipei Veterans General Hospital, Inha University, Inha University Hospital, Hanyang University Seoul Hospital, Hanyang University Medical Center, Seoul National University, Seoul National University Bundang Hospital, Ulsan University Hospital, China Medical University, China Medical University Hospital, Kyung Hee University, Kyung Hee University Hospital at Gangdong, Chang Gung Memorial Hospital, Chiayi Chang Gung Memorial Hospital
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,050
Funder: Gilead Sciences
OpenAlex ID: W4401800116