Work

Enhancing the performance of nanostructured PVA/SA scaffolds through incorporation of macromolecules: From synergistic effects to advanced multifunctionalities

Year: 2024

Type: article

Abstract: The increasing use of biomaterial scaffolds in tissue engineering applications demands a comprehensive understanding and precise control of their overall properties. This work analyzes the synergy of naturally occurring biological macromolecules on the swelling, and thermal and mechanical properties of ionically crosslinked polyvinyl alcohol (PVA)/sodium alginate (SA) fibrous scaffolds. The presence of collagen (COL) or hyaluronic acid (HA) contributed not only to increasing the hydrogen-bond density but also to induce the crystalline PVA phase formation. Consequently, the swelling, thermal degradation, elastic modulus, and nanohardness of the scaffolds were significantly enhanced. By considering COL and HA the relevance in diverse cellular processes and tissue functions, the PVA-scaffolds here introduced are promising materials by providing advanced multifunctionalities.

Source: Materials Letters

DOI: 10.1016/j.matlet.2024.137251

Authors: A. Soto-Quintero, Eduin I. González Castillo, Karla Gómez Lizárraga, Arturo Barba-Pingarrón, M. Hernández

Institution: Consejo Nacional de Ciencia y Tecnología

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $2,540

Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México