Work

Presentation of chronic myeloid leukemia in basophilic blast crisis

Year: 2024

Type: article

Abstract: Basophilia with mature and dysplastic basophils is a common phenomenon in CML. However, a basophilic blast crisis is a very rare form of acute transformation. A review of 410 patients with disease in transformation revealed only two cases (0.5%) of basophilic blast crisis.1 The dominance of basophil blast cells with fewer or no other myeloblasts or lymphoblasts confirms the diagnosis. Clonal evolution is likely to be evident with additional chromosomal abnormalities, often including i(17q) or other abnormality of chromosome 17.1-4 Diagnosis is straightforward when a patient is known to have CML but is more problematic if a patient presents already in blast crisis. The authors declare no conflict of interest.

Source: American Journal of Hematology

DOI: 10.1002/ajh.27464

Authors: Biswadip Hazarika, Barbara J. Bain

Institutions: Batra Hospital and Medical Research Centre, St Mary's Hospital, Imperial College London

Language: English

Topic: Chronic Myeloid Leukemia Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190