β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment
Year: 2024
Type: article
Abstract: . In our cell culture and molecular docking experiments, we found that β-chitosan prefers shielding the MD-2 pocket, thus blocking the activation of TLR4-MD-2 complex to suppress NF-κB signaling pathway activation. Together, our findings highlight the extensive therapeutic potential of β-chitosan in reversing aged-related/LPS-induced cognitive impairment via the liver-brain axis.
Source: iScience
Authors: Chenming Zou, Ruihua Cai, Yunbing Li, Yu Xue, Guoguang Zhang, Gulimiran Alitongbieke, Yutian Pan, Sanguo Zhang
Institution: Minnan Normal University
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,150
OpenAlex ID: W4401822334