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Linker-specific monoclonal antibodies present a simple and reliable detection method for scFv-based CAR NK cells

Year: 2024
Type: article
Abstract: , spiked in whole blood, and within patient-derived tumor spheroids with high specificity and sensitivity, providing an effective and almost universal alternative for scFv-based CAR detection. Additionally, we confirm that linker-specific antibodies can be used for functional testing and enrichment of CAR NK cells, thereby providing a useful research tool to fast-track the development of novel CAR-based therapies.
DOI: 10.1016/j.omtm.2024.101328
Authors: Katharina Schindler, Katharina Eva Ruppel, Claudia Müller, Ulrike Koehl, Stephan Fricke, Dominik Schmiedel
Institutions: Fraunhofer Institute for Cell Therapy and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology, Fraunhofer-Gesellschaft, Leipzig University, Klinikum Chemnitz, Technische Universität Dresden
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,900
Award: G662888678
OpenAlex ID: W4401825054
FWCI: 1.676
Cites: 36
Cited by: 11
Related to: 10