Fabrication of carbon dots modified electrode for electrochemical sensing of paclitaxel as an important anticancer drug
Year: 2024
Type: article
Abstract: Cancer represents a prominent health concern on a global scale and stands as a significant contributor to mortality. The accurate quantification of anti-cancer drugs such as paclitaxel in human biofluids is critical for effective treatment and monitoring. In this study, a straightforward one-step hydrothermal method was presented for synthesizing carbon dots (CDs), eliminating the need for any additional decoration or modification, by utilizing combretum micranthum extract as a natural carbon source. A paclitaxel sensor was fabricated by modifying a glassy carbon electrode (GCE) with the green synthesized CDs. At optimal conditions, the CDs-GCE exhibited a linear response for paclitaxel analysis in a range of 0.07 µM to 35 µM, with a low detection limit of 2.1 nM. The suggested sensor indicates acceptable reproducibility for paclitaxel detection ((RSD=2.6 %). In addition, the CDs-GCE depicts a good resistant versus common interfering species including flutamide , dopamine, glucose, nilutamide , lactose, tinidazole , ascorbic acid , and L -cysteine. The applicability of the sensor for paclitaxel detection in human serum and human urine samples was effectively assessed. The presented electrochemical sensing protocol for paclitaxel detection offers several merits, including a low limit of detection, fast response time, resistance to interference, and ease of use.
Source: Alexandria Engineering Journal
Authors: Wenze Sun, Bin Song, Shoushuai Li
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,300
OpenAlex ID: W4401832376