Work

New Chalcone Incorporated Structurally Modified Pyridine‐Pyrimidine Derivatives as Anticancer Agents: Their Design, Synthesis, and in‐vitro Evaluation

Year: 2024

Type: article

Abstract: Chalcone‐incorporated pyridine‐pyrimidines i.e. derivatives of (5‐(6‐(pyrimidin‐5‐yl)pyridin‐3‐yl)thiophen‐2‐yl)prop‐2‐en‐1‐one were synthesized and their structures were confirmed by analytical techniques. In addition, all the derivatives were examined for their capacity to fight against cancer towards four cell lines, including breast (MCF‐7), prostate (DU‐145 and PC3), and lung (A549) by utilizing the MTT technique and the clinically used chemotherapy medication, etoposide serving as a positive reference. All these results were expressed in IC 50 μM, and values of synthesized compounds are compared with a reference drug, showing values ranging from 1.97±0.45 μM to 3.08±0.135 μM. Among those, a few compounds 10(a–e ) demonstrated strong activities with corresponding cell lines.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202401122

Authors: Swarupa Ketha, Chithaluri Sudhakar, Shashikala Kethireddy, Laxminarayana Eppakayala

Institution: GITAM University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Gandhi Institute of Technology and Management