Carbon fiber felt scaffold from Brazilian textile PAN fiber for regeneration of critical size bone defects in rats: A histomorphometric and microCT study
Year: 2024
Type: article
Abstract: The objective of the present study was to evaluate the carbon fiber obtained from textile PAN fiber, in its different forms, as a potential scaffolds synthetic bone. Thirty-four adult rats were used (Rattus norvegicus, albinus variation), two critical sized bone defects were made that were 5 mm in diameter. Twenty-four animals were randomly divided into four groups: control (C)-bone defect + blood clot, non-activated carbon fiber felt (NACFF)-bone defect + NACFF, activated carbon fiber felt (ACFF)-bone defect + ACFF, and silver activated carbon fiber felt (Ag-ACFF)-bone defect + Ag-ACFF, and was observed by 15 and 60 days for histomorphometric, three-dimensional computerized microtomography (microCT) and mineral apposition analysis. On histomorphometric and microCT analyses, NACFF were associated with higher proportion of neoformed bone and maintenance of bone structure. On fluorochrome bone label, there was no differences between the groups. NACFF has shown to be a promising synthetic material as a scaffold for bone regeneration.
DOI: 10.1002/jbm.b.35467
Authors: Kauê Alberto Pereira, Letícia Cavassini Torquato, Clarissa Carvalho Martins Maciel, Camilla Magnoni Moretto Nunes, Ludmilla Oliveira Mantovani, Nátaly Domingues Almeida, Sergio Lucio Pereira Castro Lopes, Luana Marotta Reis de Vasconcellos, Maria Aparecida Neves Jardini, Jossano Saldanha Marcuzzo, Andrea Carvalho De Marco
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4401852621