Work

Isochalcogenourea-catalyzed asymmetric (4 + 2)-heterocycloadditions of allenoates

Year: 2024

Type: article

Abstract: Allenoates are versatile reagents that can be used for numerous (formal) cycloaddition reactions under (chiral) Lewis base catalysis. Most commonly, the catalysts of choice are phosphines, amines, and N-heterocyclic carbenes. We have recently established the use of readily available chiral isochalcogenoureas as catalysts for asymmetric (4 + 2)-heterocycloadditions of allenoates with various vinylogous acceptors. This represents a complementary approach for allenoate activation and gives access to various highly functionalized chiral dihydropyrans with good to excellent enantioselectivities and diastereoselectivities.

Source: Chemistry Letters

DOI: 10.1093/chemle/upae168

Author: Mario Waser

Institution: Johannes Kepler University of Linz

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $1,048

Funders: Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung, Austrian Science Fund