Therapeutic Drug Monitoring of Long-Acting Rilpivirine and Cabotegravir for Treatment of HIV-1 Infection—A Case Series of Five Patients With One Virologic Failure After Development of Two-Class Resistance
Year: 2024
Type: article
Study design: Case Report
Abstract: Virologic failure of long-acting rilpivirine/cabotegravir is rare but may result in severely limited treatment options. Known risk factors cannot predict all cases. Therapeutic drug monitoring (TDM) may help identify patients at risk, but reliable thresholds are missing. We report retrospective TDM in a cohort of 5 patients, including 1 virological failure.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofae480
Institutions: University of Tübingen, University of Würzburg, Universitätsklinikum Würzburg, Jena University Hospital, Friedrich Schiller University Jena, University Hospital Leipzig, Leipzig University, LMU Klinikum, Ludwig-Maximilians-Universität München, University of Kaiserslautern, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, University Hospital Frankfurt
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,256
OpenAlex ID: W4401856207