Work

Determining Ion‐Pair Binding Affinities of Heteroditopic Receptor Systems

Year: 2024

Type: article

Abstract: Determining ion-pair affinities in heteroditopic receptor systems presents a persistent and significant challenge. The plethora of technical and experimental problems implicated in measuring ion-pair affinities have encouraged the use of several expedient experimental practices as a means of characterising ion-pair recognition behaviour. Exploiting a model heteroditopic receptor system, we interrogate the reliability of these methods and demonstrate that these commonly used techniques can be highly questionable and without extreme care can lead to incorrect conclusions.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202402844

Authors: Andrew Docker, Hui Min Tay

Institutions: University of Cambridge, University of Oxford

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funders: Gonville and Caius College, University of Cambridge, Clarendon Fund