Work

Single-molecule force spectroscopy shows that side chain interactions govern the mechanochemical response of polypeptide α-helices and prevent the formation of β-sheets

Year: 2024

Type: article

Abstract: AFM single-molecule experiments on poly( l -glutamic acid) and poly( l -lysine) show that hydrophobic side chain interactions stabilize α-helices and inhibit the formation of a metastable β-sheet-like structure under mechanical deformation.

Source: RSC Mechanochemistry

DOI: 10.1039/d4mr00068d

Authors: Marie Asano, Damien Sluysmans, Nicolas Willet, Colin Bonduelle, Sébastien Lecommandoux, Anne-Sophie Duwez

Institutions: Centre National de la Recherche Scientifique, University of Liège, Laboratoire de Chimie des Polymères Organiques, Institut Polytechnique de Bordeaux

Language: English

Topic: Force Microscopy Techniques and Applications

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: diamond

Funders: Fonds De La Recherche Scientifique - FNRS, Education, Audiovisual and Culture Executive Agency

Award: G4511935149