Work

Serum TLR2 and TLR9 in Prostate Cancer Patients in Relation to EBV Status

Year: 2024

Type: article

Abstract: The relationship between Toll-like receptors (TLRs) and prostate cancer (PCa) is complex due to the presence of the Epstein-Barr virus (EBV) infection, which has been identified as a predisposing factor for some cancers, including PCa. The present study aims to investigate these complex links by examining the levels of selected TLRs and the potential impact of EBV infection on PCa. Therefore, we examined the serum of patients with PCa. The study compared EBV(+) patients to risk groups, the Gleason score (GS), and the T-trait. Additionally, the correlation between TLR and antibody levels was examined. The results indicated that higher levels of TLR-2 and TLR-9 were observed in more advanced PCa. The findings of this study may contribute to a deeper understanding of the role of viral infections in PCa and provide information on future strategies for the diagnosis, prevention, and treatment of these malignancies.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms25169053

Authors: Dominika Sikora, Jacek Kiś, Ewa Stępień, Bartłomiej Drop, Małgorzata Polz-Dacewicz

Institutions: Medical University of Lublin, 1 Military Clinical Hospital with Outpatient Clinic

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,296