Work

Targeting heterozygous dominant negative variant of KCNA2 using Gapmer ASO for the treatment of drug-resistant epilepsy

Year: 2024

Type: article

Abstract: 1.2_P407R over the WT protein expression, reversing the broadening of action potential duration, abrogating the EAD and leading to overall increase in potassium current.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2024.102316

Authors: Hua Huang, Dong Rui Ma, Derrick Wei Shih Chan, Adeline Seow Fen Ngoh, Dejie Yu, Shi Jun Ng, John Jia En Chua, Eng King Tan, Hui-Lin Chin, Denise Li Meng Goh, Tuck Wah Soong

Institutions: National University of Singapore, Life Sciences Institute, Singapore General Hospital, Duke-NUS Medical School, KK Women's and Children's Hospital, National Neuroscience Institute, National University Hospital, National University Health System

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Ministry of Health -Singapore, Ministry of Education - Singapore, Ministry of Education, India

Awards: G270578524, G2850331844, G4122916522

OpenAlex ID: W4401929422

FWCI: 1.608

Cites: 28

Cited by: 6

Related to: 10