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Figure 1 from Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures

Year: 2024

Type: other

Abstract: ssSEs identify highly expressed genes unique to the ADRN and MES lineages. A, H3K27ac deposition on ADRN and MES SEs and ssSE in each neuroblastoma cell line. Peaks are higher for ssSEs than double-stranded SEs. B, H3K27ac deposition, KAS-seq pulldown, and RNA expression at MES ssSE, denoted in red, associated with a MES signature gene LUM in representative ADRN and MES isogenic cell lines and C, a ADRN signature gene PRIMA1 in the same representative cell lines. D, Heatmap representing 532 differentially expressed genes that were identified in five ADRN and three MES cell lines in proximity to ssSEs (P < 0.05).

DOI: 10.1158/2767-9764.26861882.v1

Authors: Maria E. Kaufman, Omar R. Vayani, Kelley Moore, Alexandre Chlenski, Tong Wu, Sang Mee Lee, Ami V. Desai, Chuan He, Susan L. Cohn, Mark A. Applebaum

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4401959673

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