Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.
Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Executive dysfunction is characteristic of behavioral variant frontotemporal dementia (bvFTD) but can be challenging to detect. Dispersion-based intraindividual variability (IIV-d) is hypothesized to reflect a sensitive index of executive dysfunction and has demonstrated relevance to functional decline but has not been evaluated in bvFTD. METHOD: We report on 477 demographically matched participants (159 cognitively healthy [CH], 159 clinical Alzheimer's disease [AD], 159 clinical bvFTD/prodromal bvFTD) who completed the Uniform Data Set 3.0 Neuropsychological Battery. IIV-d was measured using the coefficient of variance (CoV; raw and demographically adjusted) across 12 Uniform Data Set 3.0 Neuropsychological Battery indicators and the informant-rated Functional Activities Questionnaire assessed daily functioning. RESULTS: = .38). Both CoV metrics accurately differentiated the bvFTD/prodromal bvFTD and CH groups (areas under the curve = .84), but not bvFTD/prodromal bvFTD and AD groups (areas under the curve = .59). Regression analyses in the bvFTD/prodromal bvFTD group indicated that higher IIV-d on both metrics was associated with greater daily functioning impairment, over and above covariates. CONCLUSIONS: Compared to healthy adults, individuals with bvFTD/prodromal bvFTD show greater levels of performance variability across a battery of neuropsychological measures, which interferes with everyday functioning. These data demonstrate the clinical utility and ecological validity of IIV-d in bvFTD/prodromal bvFTD, though these findings should be replicated in more diverse samples. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Source: Neuropsychology
DOI: 10.1037/neu0000969
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1017046091, G1053905225, G1058506282, G1104192986, G113062254, G11426272, G1171648585, G1228824270, Michigan Alzheimer's Disease Core Center, UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, G1375833519, G1417337112, G1492531059, G1602633198, G1663213784, G1778344677, G2075747288, G2190936067, G219693323, G2234397790, G234895681, G2515091901, Neurobiology of Alzheimer's Disease and Aging, G2622865600, G2640555407, G2769554943, G2984989008, G3036763132, G3066742295, G3335858628, G3359100610, G343469054, G3439557519, G348743638, G384347443, G3919444319, G3946457848, G40706755, G4076092645, G4103239427, G413369726, G415047313, G4186766937, Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC), G423967958, G4318823550, G4390231255, G4417220376, G4684857399, UAB Alzheimer's Disease Research Center, G496605150, G511679733, G556672640, G5977822913, G603598372, G611802359, G6492025387, University of Kansas Alzheimer's Disease Core Centers, G6750444795, New Mexico Alzheimer's Disease Research Center, Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, G726963014, G7380798711, G7409097460, Boston University Alzheimer's Disease Center, Alzheimer's Disease Core Center, G8018240826, University of Florida - Mt. Sinai Medical Center AD Research Center, G828200374, G873702183, G9000000531, G9000003466, G9000004804, G9000005508, G9000008846, G9000013408, G9000015941, G9000017672, G9000018678, G9000020322, G9000021351, G9000024008, G9000025891, G9000030722, G9000031515, G9000032698, G9000033698, G9000035486, G9000036492, G9000044543, G9000046703, G9000056371, G9000064269, G9000070217, G9000074900, G9000082286, G9000091371, G9000092781, G9000104082, G9000108235, G9000115539, G9000119544, G9000126115, G9000131182, G9000132673, G9000145746, G9000147311, G9000151373, G9000167101, G9000208643, G9000208846, G9000212151, G9000218452, G9000218858, G9000227227, G9000227779, G9000252716, G9000274623, G9000290608, G9000305967, G9000307348, G9000352745, G9000354213, Arizona Alzheimer's Disease Research Center
OpenAlex ID: W4401991870