The Q for immune evasion in HCC: ER stress in myeloid cells
Year: 2024
Type: article
Abstract: Figure 1 A glutamine metabolism-ER stress-immune evasion axis in HCC.In HCC, metabolic competition with tumour cells leads to glutamine/Q shortage in myeloid cells.Q shortage induces ER stress in myeloid cells and increases the expression of the vitamin B 3 receptor GPR109A.GPR109A activation results in immunosuppressive polarisation and additional recruitment of myeloid cells.Subsequently, antitumour CD8+ T-cell immunity is impaired.ER, endoplasmic reticulum; HCC, hepatocellular carcinoma.
Source: Gut
Authors: Charlotte Rennert, Maike Hofmann
Institutions: University of Freiburg, University Medical Center Freiburg
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4401992544