Work

Glymphatic clearance is enhanced during sleep

Year: 2024

Type: preprint

Abstract: We here revisited the concept that glymphatic clearance is enhanced by sleep and anesthesia. Utilizing dynamic magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and fluorescent fiber photometry, we report brain glymphatic clearance is enhanced by both sleep and anesthesia, and sharply suppressed by wakefulness. Another key finding was that less tracer enters the brains of awake animals and that brain clearance across different brain states can only be compared after adjusting for the injected tracer dose.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2024.08.24.609514

Authors: Erik Kroesbergen, Laurence V. Riesselmann, Ryszard S. Gomolka, Virginia Plá, Tina Esmail, Visti H. Stenmo, E. Rebeka Kovács, Elise S. Nielsen, Steven A. Goldman, Maiken Nedergaard, Pia Weikop, Yuki Mori

Institutions: University of Copenhagen, University of Rochester Medicine, University of Rochester

Language: English

Topic: Cerebrospinal fluid and hydrocephalus

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Neurological Disorders and Stroke

Awards: Transcriptional Determinants of the Fate Trajectories of Single Human Glial Progenitor Cells in Response to Demyelination in Vivo, Cell-intrinsic and contextual determinants of aging by human glial progenitor cells

OpenAlex ID: W4401995823

Cites: 25

Cited by: 32

Related to: 10