Depressive Symptoms and Left Ventricular Diastolic Dysfunction Among Men and Women with HIV
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background and Aim: The prevalence of depressive symptoms and major depressive disorder is high among adults living with HIV. Depressive symptoms are associated with increased cardiovascular disease risk. This study examined the association between depressive symptoms and echocardiographic indices of left ventricular diastolic dysfunction (LVDD) among men and women living with and without HIV. Methods: and HIV RNA viral load <499 copies/mL. The presence of LVDD was defined according to the Characterizing Heart Function on Antiretroviral Therapy (CHART) criteria. Secondary outcomes were continuous values of each component of the CHART criteria: left ventricular ejection fraction >50%, septal e' velocity, lateral e' velocity, left atrial volume index, left ventricular mass index, and relative wall thickness. Logistic and linear regression were used to adjust for sociodemographic, behavioural, cardiometabolic, and HIV-related factors. Results: Among 874 men (51% with HIV) and 1,191 women (76% with HIV), in whom the overall prevalence of LVDD was 22.5% and depressive symptoms 30.8%, depressive symptoms were not significantly associated with LVDD. The associations between individual LVDD components and depression were in the small to medium range, though generally not significant. Conclusion: Findings warrant further research regarding the association between LVDD and depressive symptoms in the era of combination antiretroviral therapy.
Source: EMJ Cardiology
Authors: Claudia Martinez, Nel Jason Haw, Violeta J. Rodriguez, Jorge R. Kizer, Wendy S. Post, Katherine C. Wu, Joao A. C. Lima, Jenni M. Wise, Maria L. Alcaide, Michael Plankey, Deborah Konkle-Parker, Sofia Kozlova, Margaret A. Fischl, Adaora A. Adimora, Matthew Budoff, Yasmeen Golzar, Jason Lazar, Frank J Palella, Carlos J. Rodriguez, Andrea M. Weinstein, Gina Wingood, Amanda Blair Spence, Heather McKay, Deborah L. Jones
Institutions: University of Miami, Johns Hopkins University, University of Illinois Urbana-Champaign, San Francisco VA Medical Center, University of California, San Francisco, San Francisco VA Health Care System, University of Alabama at Birmingham, Georgetown University Medical Center, University of Mississippi Medical Center, University of North Carolina at Chapel Hill, University of California, Los Angeles, Cook County Health and Hospitals System, SUNY Downstate Health Sciences University, Northwestern University, Albert Einstein College of Medicine, University of Pittsburgh, Columbia University
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: Bristol-Myers Squibb, Pfizer, Northwestern University, Georgia Clinical and Translational Science Alliance, National Institutes of Health, University of California, San Francisco, Center for AIDS Research, University of Alabama at Birmingham, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities, Center for AIDS Research, University of North Carolina at Chapel Hill, Clinical and Translational Science Institute, University of California, Los Angeles
Awards: G1034546755, G12089860, G1296759572, G1329112180, G1400602301, G155333157, G1655989834, G1773452051, G1787625665, G183157880, G1849940085, G1913134163, G192128497, G1972383081, G2008237588, G2127051194, G2334180555, G248584506, G255204022, G2755707676, G2759654445, G2839061624, G2908277772, G30074556, G311558797, G319781266, G3242306066, G3418878615, G343705321, G3630727822, G3671922257, G3869857964, G4016133911, G4044828089, G4535678174, G456742281, G483408255, G5078796989, G5147848267, G521591464, G5431849782, G5525419549, G5660189159, G5691055145, G5747858550, G5863844756, G5900455136, G6396423216, G6745172908, G693265041, G6990385686, G7152846654, G775892330, G7760075911, G7807729167, Johns Hopkins Institute for Clinical and Translational Research, G9000010044, G9000016284, G9000025681, G9000030090, G9000030772, G9000031392, G9000037749, G9000039899, G9000041916, G9000050451, G9000066220, G9000080293, G9000082816, G9000088144, G9000093720, G9000102070, G9000108991, G9000126122, G9000126231, G9000132212, G9000146713, UNC MACS/WIHS Combined Cohort Study Clinical Research Site, Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS), UAB Center for AIDS Research (CFAR)
OpenAlex ID: W4401996012