Work

Assessing the Effect of Magnetite Nanoflowers on Platelets in a Multiscale Approach in the Context of Thromboembolic Diseases

Year: 2024

Type: article

Abstract: Iron oxide magnetic nanoparticles have emerged as promising theranostic agents for the treatment of cardiovascular diseases. Using a multiscale approach, we investigated the interaction of 26.5 nm diameter multicore magnetite nanoflowers, recognized for being excellent nanoheaters and contrast agents in nanomedicine, with human blood platelets. Using flow cytometry, we determined safe concentrations of magnetite nanoflowers. Data indicated that platelets exhibit reversible activation at high magnetite nanoflower concentrations. Magnetic resonance imaging revealed significant reductions in T 1 and T 2 relaxation times when platelets were combined with magnetite nanoflowers at high concentrations suggesting nanoparticle–platelet interaction. At the nanoscale, transmission and scanning electron microscopy confirmed morphological changes in platelets when exposed to a high concentration of nanoparticles and their partial internalization in the platelets. Overall, the findings support the theranostic potential of magnetite nanoflowers in whole blood for thromboembolic disease management, with the potential for future investigations over longer exposure.

Source: ACS Applied Nano Materials

DOI: 10.1021/acsanm.4c02715