Work

The study findings demonstrated a significant association between C-reactive protein levels and trabecular bone score : NHANES 2005–2008

Year: 2024

Type: article

Abstract: OBJECTIVES: The association between C-reactive protein and bone density has been primarily investigated in previous studies, with little to no research investigating its relationship with total bone trabecular score. METHODS: Data from the NHANES database (500 males and 633 females) were utilized in this study to perform a multiple weighted linear regression analysis to estimate this relationship of CRP and TBS. Subsequently, population characterization, univariate logistic regression analysis, subgroup and interaction analysis were in progress. RESULTS: Upon covariate adjustment, the analysis revealed a notable negative correlation between CRP and TBS(β=-0.0081,95% CI (-0.0142, -0.0019), P = 0.009). Furthermore, no interactions were detected within any subgroups. CONCLUSION: This finding enhances our comprehension of the relationship in inflammation and bone health, offering the novel research outlook for the treatment and prevention of osteoporosis and osteoporotic fractures.

Source: Journal of Orthopaedic Surgery and Research

DOI: 10.1186/s13018-024-05014-1

Authors: Huangze Yan, Shenjie Wang, Huikun Cao, Haobo Zhong, Chunhan Sun

Institutions: Guangdong Medical College, Huizhou Central People's Hospital

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890