Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction
Year: 2024
Type: article
Abstract: concentration increased in RASMCs following CIH modeling, which was reversed by BK channel activation. BK channel inhibitor (Iberiotoxin) exacerbated CIH-induced vascular disorders and endothelial dysfunction. BK channel activation promoted vasorelaxation while suppressing vascular endothelial dysfunction, inflammation, and oxidative stress, thereby indirectly improving CIH-induced vascular dysfunction.
Authors: Ping Zhang, Pengtao Zou, Xiao Huang, Xianghui Zeng, Songtao Liu, Yuanyuan Liu, Liang Shao
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402025194